When the country singer ex-wife of a U.S. president is sensationally murdered during a concert performance, forensic psychiatrist Jo Beckett endeavors to learn the victim's role in her demise as well as the murder's relevance for the president.

Forensic psychiatrist Jo Beckett is called to the scene of an aircraft inbound from London to help deal with a passenger who is behaving erratically. She figures out that he's got anterograde amnesia, and can't form new memories. Suddenly a string of clues arises, something to do with a super deadly biological agent code-named "Slick," a missing wife and son, and a secret partnership gone horribly wrong. Jo realizes her patient's addled mind may hold...

Dr. Jack Gramm is a college professor who moonlights as a forensic psychiatrist for the FBI. Gramm receives a death threat claiming he has only 88 minutes to live. Now he has to put together the clues and try and solve the biggest crime of his career. He narrows down the possible suspects, who include a disgruntled student, a jilted former lover, and a serial killer who is already on death row, all before his time runs out.